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Both -MSH and ET-1 upregulate the expression of MCR1 and positively influence pigmentation [63]

By lowering oxidative stress and supporting immune balance, it can ease seasonal allergy symptoms and improve tolerance to environmental triggers

Therefore, developing a comprehensive therapeutic platform capable of spatiotemporal ROS scavenging, regulation of macrophage polarization, and enhancement of angiogenesis and cell proliferation represents a critical research focus for improving clinical outcomes in chronic diabetic wound management