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10.1038/srep19272 122 YuG.LuoF.NianM.LiS.LiuB.FengL.et al (2021)

AMPK activators, such as metformin, have demonstrated potential in treating metabolic diseases by enhancing autophagy to improve metabolic homeostasis ( 4.2.3 Class III PI3K/Beclin1 complex pathway The class III PI3K/Beclin1 complex is a core functional unit within the autophagy regulatory network, playing a pivotal role in the initiation and elongation of autophagosome formation (Ye et al., 2023)