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Access this article Similar content being viewed by others Data availability All data and materials generated or analyzed during this study are included in this published article

Pregnant women or those with medical conditions are advised to consult a doctor before treatment.

Collectively, the data indicate that downregulation of DUSP22 in T cells leads to T cell-mediated inflammation and SLE nephritis

Third, PA calcification has been linked to hypoxia, in that hypoxia decreases the expression of serine protease granzyme B stored in the granules of T lymphocytes and natural killer cells, which inhibits store-operated calcium channels (SOCCs) as the main source of calcium mineral by attenuating non-canonical Wnt signals in SMCs, thus increasing calcification of the PA (141)