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Some individuals may experience noticeable improvement sooner, while others may require longer or show milder effects

There seem to be some genetic components that we're finding

doi: 10.1038/mp.2011.52 62 GhosalK.StathopoulosA.ThomasD.PhenisD.VitekM

Sirt1 deletion in osteoblasts inhibited glycolysis by directly binding to and increasing the acetylation level of GOT1 to maintain bone homeostasis (60)