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Brain Res 1701:8592 Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah I, Van de Water J (2011) Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome

doi: 10.1007/s13205-019-1991-2

Yes, there are various topical treatments available for melasma, including creams and serums containing ingredients like vitamin C, retinol, and hydroquinone