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In these models, the penetration kinetics of fluorescently labeled ID-ADCs can be visualized through confocal microscopy, enabling researchers to determine whether the conjugates can effectively diffuse into the hypoxic and necrotic core of the granuloma or if they are restricted to the more permeable peripheral layers ( In vitro biofilm models that replicate the shear stress and nutrition gradients of clinical situations, such as catheter-associated infections or cystic fibrosis-related lung infections, are essential for evaluating ID-ADC efficacy against biofilm-embedded bacteria

and 4) its pleiotropic roles mediating cellular functions reminiscent of cancer hallmarks, including proliferation, migration and invasion, and inhibition of apoptosis [15, 18, 19]

Abnormalities in brain energy metabolism are observed in a variety of pathological conditions such as neurodegenerative diseases, stroke, epilepsy, and migraine

Mills AC, Hofstetter WL, Mehran RJ, Rajaram R, Rice DC, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Antonoff MB