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Notably, current strategies targeting lipids are not brain-specific and affect peripheral lipid biosynthesis, which is associated with increased triglyceride levels and side effects such as liver steatosis [219]

However, it has been shown that the CHAC1 protein, found in higher eukaryotes, has -glutamylcyclotransferase activity and also specifically degrades intracellular glutathione

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Structurefunction and comparator work: In vitro evaluation has positioned it within comparative assays and mechanism-led screening involving short hGH-derived fragments