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J Immunol 180 : 38663873

Two studies from two different institutions recently identified a novel iron death signaling pathway independent of GPX4 (Bersuker et al., As an essential intracellular antioxidant, reduced glutathione (-L-glutamyl-L cysteinylglycine, GSH) synthesis requires the cystine/glutamate antiporter system (encoded by SLC7A11 ) to import cystine from the environment and reduce it to cysteine

Tumor lysate vaccines are safe and well tolerated in clinical trials of GBM patients, and induce an immune response against cancer [140]

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