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First, glutathione is converted into glutathione disulfide (GSSG) by glutathione reductase

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The wide differential diagnosis can be narrowed considerably by checking the mean cell volume (MCV) and the reticulocyte count and initially classifying the anaemia as: Microcytic, MCV 100 fl Microcytic anaemia The three most common causes for microcytic anaemia are: Iron deficiency Thalassaemia Anaemia of Chronic disease A suggested approach to laboratory testing is shown in Figure 3