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The same studies also determined that tumors treated with PD-1/PD-L1-monoclonal antibodies (mAbs) endowed with blocking properties developed resistance through the metabolic upregulation of CD38, akin to that induced by all-trans retinoic acid (ATRA) and interferon- in the TME (as in non-small cell lung cancer, NSCLC)

Animal studies report wide therapeutic windows

More recently, another study explored NAM supplementation in a golden retriever muscular dystrophy model, demonstrating increased NAD + levels in skeletal muscles and improved skeletal muscle function 266