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[113] Although serious adverse events were absent, the necessary reduction in toxic porphyrin precursors ALA and PBG was not observed, perhaps because higher doses and more efficient vectors are required to obtain therapeutic expression of the transgene

Nevertheless, the complex manufacturing processes of PLGA-lipid hybrids can limit large-scale production, and delicate formulation design is essential to minimize potential cytotoxicity arising from NP-cell interactions [91]

In vitro and in vivo evaluation of clinically-approved ionizable cationic lipids shows divergent results between mRNA transfection and vaccine efficacy

vivax is the absence of a long-term culture that produces gametocytes to infect mosquitoes