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A total of 12,519 patients met the inclusion criteria for the primary dose analysis, and their clinical data on dose escalation and weight change during the first two years after semaglutide initiation were assessed in relation to cardiovascular outcomes during the subsequent two years

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While early and smaller trials showed promising fat-loss effects, the largest Phase IIb trial did not achieve statistical significance in humans for its primary endpoint of weight reduction, which led to the program being discontinued

Serious adverse effects are rare but have been reported, particularly with IV administration of thiamine