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By interfering with these processes, chemotherapeutic medications can cause ER stress and an accumulation of unfolded or misfolded proteins in the ER lumen that triggers the unfolded protein response (UPR), a signalling network that aims to restore ER homeostasis

Puts et al., 2017)

How dying cells alert the immune system to danger

Although more research is called for, one could avoid overconsumption of foods high in glutamate or MSG to avoid the risk of glutamate-related anxiety or other symptoms