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While the effects of peroxynitrite within the tumor microenvironment are not yet fully understood, it seems to contribute to immunosuppression and the protection of cancer from the immune system

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In this review, we explore the complex interplay between sleep, metabolism, and aging across five core themes: (1) the role of sleep in maintaining optimal free radical levels, (2) whether ROS directly contribute to or mediate sleep disturbances in aging, (3) how age-related sleep disturbances may, in turn, contribute to impaired brain metabolism and exacerbate age-related changes, (4) the role of sleep, redox, and aging in peripheral systems, and (5) the evidence that improving mitochondrial redox potential restores sleep and slows aging, as well as the potential benefits of interventions like exercise, antioxidant-rich foods, supplements, and specialized diets that enhance sleep and/or metabolic efficiency, and their effects on aging markers (summarized in Figure 1)