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HIF-1 (Hypoxia-inducible factor-1 alpha): In hypoxic tumor environments, HIF-1 becomes stabilized and promotes the transcription of numerous genes involved in angiogenesis, including VEGF

Hodkov J, Preisler J, Foret F, Kubn P

It does this by modulating NF-B and AP-1 pathways, thereby exerting anti-inflammatory and antitumor effects with minimal gastrointestinal irritation (Goel et al., 2001)