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Many of the oxidative stress biomarker profiles are altered in ALS bio-samples and animal models, where it has been observed that oxidative stress promotes the aggregation of acetylated TDP-43 which hinders RNA binding and encourages the accumulation of insoluble, hyperphosphorylated TDP-43 species

The Molecular Basis of Spinocerebellar Ataxia Type 7

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In thesis, obesity-related metabolic dysfunction could hinder the expected epigenetic responses, potentially due to factors such as increased folate utilization, higher urinary excretion, blood volume dilution, tissue distribution differences, and endocrine alterations [41, 42]