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5-Amino-1MQ's mechanism centers on NNMT inhibition: NNMT inhibition : Selectively blocks NNMT with an IC50 of approximately 1.2 microM

In experimental models, researchers became interested in its ability to influence inflammatory reactions and cartilage metabolism

Although its the most common form in the UK, PA is still considered a rare disease, with the Journal of Blood Medicine estimating that it affects 0.1% of the general population