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SAM is an essential cofactor in the pathway of synthesis of epinephrine, which is involved in learning processes and memory consolidation [29, 30]

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Considering that RGMa has a potential to induce cleaved caspase 3-mediated cell death in immature neurons 31 , RGMa upregulation likely impairs the survival of DCX-positive immature neurons, leading to a reduction in their number under diabetic condition

Acknowledgements The authors would like to thank Debbie Day (Axis, a division of Spirit Medical Communications Group Ltd.) for medical writing and editorial assistance