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norepinephrine increases both total peripheral resistance, as well as systolic and diastolic blood pressure Note : Compensatory vagal reflexes tend to overcome the direct positive chronotropic effects on the heart (since both branches of the ANS innervate the SA node), but do not eliminate the positive inotropic effects on the ventricle (which does not have significant vagal innervation)

Markovic J, Borras C, Ortega A, Sastre J, Vina J, Pallardo FV

Elevated DIO3 can be indicative of thyroid disease, as DIO3 catalyzes conversion of active thyroid prohormones and hormones into inactive forms

Neuroreport 19(16):15891592