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It acts as a scaffold protein that is necessary for the integrity of the complex, and facilitates substrate recognition via binding sequences in certain mTORC1 targets, called TOS (TOR signaling motifs) (Nojima et al., 2003

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118), and are reversed by re-establishing normal lysosomal pH directly with lysosome-targeted acidic nanoparticles 94,108 or by pharmacologically restoring lysosomal pH 94,119,122126