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Biologics The exact causes of injection site reactions due to biologics A 2023 review of 158 studies found that injection site reactions occur in Out of the 16 medications in the review, the one responsible for the most injection site reactions was canakinumab, while secukinumab had the least

Experimental models show that combined vitamin D and melatonin supplementation restores mitochondrial morphology, decreases mtDNA damage, and improves follicular development (217, 218)