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Regarding uvaol, it is not described in the literature to reduce phagocytosis, although a possible explanation would be the effects visualized in Raman spectroscopy related to the cell membrane and/or by membrane stiffness increase induced by this triterpene ( Moreover, cells increased the production of mtROS

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Moreover, exposure of cancer cells to stimuli such as hypoxia, radiation and chemotherapy causes cell damages and leads to protein degradation, resulting in increased levels of TCA cycle intermediates and in an enhanced haem biosynthesis 49,50