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In the melanoma mice model, Bose and coworkers found that a treatment regimen comprising a 7-day course of axitinib (0.5 mg/day provided orally) in combination with a vaccine (ovalbumin (OVA) peptide-pulsed syngenic dendritic cells (DCs) adenovirally-engineered to produce anti-angiogenic cytokine IL-12p70) caused remarkable protection versus melanoma progress and prolonged OS when compared to mice receiving each agent alone [125]

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Coordination chemistry is the study of how metal ions form complexes with surrounding ligands