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In short, in 96-well low-attachment U-bottom plates (Corning), we assembled (as described below) 1 h-HepOrg with 25 portal fibroblasts and 25, 50, 100 or 200 cholangiocytes, or with 100 cholangiocytes and 50 or 100 portal fibroblasts

reported that the selective blockade of respiratory chain complex I by MPP + induces dopaminergic neuronal degeneration and PD symptoms, suggesting that defects in the respiratory chain play a role in the pathogenesis of PD [82]

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h , Doseresponse curves for control (sgCtrl) and CRBN KO (sgCRBN) HCT116 cells treated with SMART1 or SMART1Et for 72 h (4 independent experiments)