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CYP2D6 may also contribute to the formation of NAPQI, albeit to a lesser extent than other P450 isozymes, and its activity may contribute to paracetamol toxicity, in particular, in extensive and ultrarapid metabolizers and when paracetamol is taken at very large doses.[18] The metabolism of paracetamol is an excellent example of toxication, because the metabolite NAPQI is primarily responsible for toxicity rather than paracetamol itself

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Reprod Toxicol 111:110 Yin D, Zhong Y, Ling S, Lu S, Wang X, Jiang Z (2024) Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers

NS) but ghrelin induced a long-lasting decrease in intraballoon volume (184 (31) v 126 (21) ml in the first 60 minutes