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The anecdata seem to indicate that the mode of delivery, that is whether or not systemic or local, doesn't seem to matter that much

Matrix metalloproteinases (MMPs), a class of metalloendopeptidase produced by tumor cells and supportive cells, allow for the degradation of the basement membrane as well as the extracellular matrix surrounding pre-existing capillaries, typically postcapillary venules [30, 31]

Therefore, a high amount of pheomelanin must be present for a lighter skin tone, and eumelanin should be less concentrated

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