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Network pharmacology and experimental validation to reveal the anti-hepatitis B virus pharmacological mechanism of Phyllanthus urinaria L

The application of stimuli-responsive nanocarriers for targeted drug delivery

30 In vivo studies in lymphocytic choriomeningitis virus-infected mice have shown that mTORC2 prevents ferroptosis in virus-specific memory CD4 T cells by limiting lipid peroxidation and mitochondrial ROS accumulation, primarily through activation of AKT and inhibition of GSK3, thereby supporting their long-term survival

The effect depends on dose, timing, and whether the DAC or non-DAC version is used