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The lipid peroxidation is a free radical-driven reaction that primarily affects polyunsaturated fatty acids (PUFAs) in cell membranes, the product of which gradually increases during the ferroptotic cell death, from the initial lipid hydroperoxides (LOOHs) to the later production of malondialdehyde (MDA) and 4-hydroxynenoal (Kagan et al., 2017)

The HSP90 inhibitor, 17-AAG, influences the activation and proliferation of T lymphocytes via AKT/GSK3 signaling in MRL/lpr mice

4 Research progress of the serine synthesis pathway in pan-cancer The transcriptional expression differences of key enzymes in the de novo serine synthesis pathway (including PHGDH, PSAT1 and PSPH) across pan-cancer specimens were systematically analyzed using the Timer online database ( Figure 2 ), revealing the expression heterogeneity and potential tumor-specific expression patterns of these enzymes in distinct cancer types

Here, we addressed our mechanistic models experimentally using ScGrx7 as a reference enzyme 11,12,18