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The inflammatory response is further exacerbated in lung injury, leading to diffuse damage to alveolar epithelial cells, decrease in lung surface-active substances, destruction of the alveolar walls, increased permeability of the basolateral membranes, accumulation of intra-alveolar fluid, accumulation of polymorphonuclear leukocytes, parenchymal cell damage, and interstitial edema (Meng et al., 2018)

Basic residues in the basic motif and first helix of the PIF4 bHLH domain are indispensable for thermomorphogenesis Observing that basic residues in the C4 segment are required for PIF4 phase separation, we generated single-insertion PIF4pro::PIF4 mBH and PIF4pro::PIF4 mB lines in the pif4 background to assess their contribution to thermomorphogenesis (Fig

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