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We speculate that conformational movement causing a structural rearrangement of the flexible loop may bring these two Cys residues closer

Zhang Z, Li Z, Li S, Xiong B, Zhou Y, Shi C

NMDA receptors are thought to play a role in neuronal hyperexcitation, a likely mechanism of tinnitus

For the initial treatment of vitamin B12 deficiency, the usual dose is 100mcg SC/MC, given every day for 10-15 days, followed by maintenance treatment