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This stimulates the secretion of pro-inflammatory cytokines (such as IL-1 and TNF) that can reinforce and amplify a pro-inflammatory function/phenotype of islet resident macrophages and activate apoptotic pathways within -cells (66)

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B12 has several functions, all of them an integral part of a healthy immune system: - B12 promotes red cell synthesis (the development and maintenance of red blood cells)

This article does not assert that the four components produce additive, synergistic, or otherwise interacting effects when combined in any model system