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This trial evaluated the safety and tolerability of both single ascending doses and multiple ascending doses of Molgramostim in humans

The major sensitivity of mitochondrial DNA to ROS-induced mutagenesis is intuitive, as this DNA is not protected by histones, and mitochondria lack the nucleotide excision repair (NER) enzymatic system

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Mitochondrial DNA copy numbers in pyramidal neurons are decreased and mitochondrial biogenesis transcriptome signaling is disrupted in alzheimer's disease Hippocampi