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4 Discussion Compared with RG group, more reductions of Scr, BUN, UA, and better improvement of eGFR were observed in RG + CHF group

They are not just metabolic byproducts but also act as important second messengers that regulate biochemical pathways, transcriptional programs, and the epigenetic states necessary for cellular functions, including cell proliferation and differentiation [5, 6]

To clarify their relative importance, we examined Cyp7a1 induction in response to oral glucose loading in Kir6.2 deficient mice ( Kir6.2 / mice), which lack glucose-stimulated insulin secretion 13