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26, 19661975 10.1161/01.ATV.0000232525.65682.a2 [DOI] [PubMed] [Google Scholar] Dermietzel R., Krause D., Kremer M., Wang C., Stevenson B

10.1136/ip.2010.029215.951 20 FlanaganS

The C677T variant specifically results in a 30-70% reduction in enzyme activity, likely due to the fact that the alanine to valine amino acid change makes the overall enzyme more heat-sensitive