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NLR was considerably greater in PD patients than controls (Muoz-Delgado et al., 2021)

3 Emerging roles of palmitoylation in inflammatory signaling pathways 3.1 TLR pathway Toll-like receptors (TLRs) play a crucial role in inflammation and host defense by recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) (55, 56)

2021 NEJM): 1961 patients, 14.9% weight loss at 68 weeks

It is tied to a less favorable metabolic profile and often makes patients feel like they are doing a lot of work without seeing the result they expected