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3 Methylfolate is the only form of folate that can cross the blood-brain-barrier, where it is required as a cofactor in the production of serotonin, dopamine and norepinephrine

10.1163/156856208784909435 J

Preclinical approaches to reduce hepatotoxicity include nanoparticle encapsulation with hepatocyte-avoidant peptides, which reduce liver uptake by up to 90%, or co-administration with PPAR agonists to enhance lipid clearance [228]