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Frataxin as a Kinetic Activator of Persulfide Transfer to ISCU Biochemical Assays Point to an Acceleration of Persulfide Transfer by Frataxin To establish the physiological function of FXN in Fe-S cluster biogenesis, the FDX2-based reaction was studied in a stepwise manner (Gervason et al., 2019)

doi:10.2147/NSS.S124657 112

Due to the substrate specificity of different esterases, the enzymatic consideration should be systematically incorporated into the early design stage

The highest thiolate oxidizability of GSH (383 mV) belongs to the microspecies in which all other basic sites in the molecule are in non-protonated form