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However, the inner gate is substantially reconfigured in the shift from the inward-facing open states to the CtAtm1 inw-opn-occl conformation, reorienting the N395 and F396 pairs, first pointing toward and away from the cavity, respectively, and then vice versa (Fig

32 Moreover, aging is closely associated with oxidative stress, and aged mice showed reduction of stress tolerance, lower GSH/GSSG ratio and higher MDA levels in the liver compared with young mice