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In severe cases, adults may develop osteomalacia (soft bones), whilst children may develop rickets Fatigue and low mood : Persistent tiredness and depressive symptoms, though there is no official link definitively established between vitamin D levels and mood disorders Increased infection susceptibility : Some evidence suggests a link with recurrent respiratory infections, though clinical trial evidence is mixed and benefits appear modest Hair loss : Some observational studies have associated diffuse hair thinning with low vitamin D levels, though this relationship requires further research Vitamin B12 deficiency typically develops gradually and can cause significant neurological and haematological complications: Anaemia symptoms : Fatigue, pallor, shortness of breath, and palpitations due to megaloblastic anaemia Neurological manifestations : Paraesthesia (pins and needles), particularly in hands and feet

Figure 2 In the methylation cycle, methionine is activated by the addition of an adenosyl group from ATP to form S-adenosylmethionine (SAM)

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Thymosin alpha 1 for the treatment of chronic hepatitis B and C virus infections