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Inhibition of the p62-KEAP1-NRF2 antioxidant signaling pathway can significantly enhance the anticancer activity of erastin and sorafenib in liver cancer cells in vivo and in vitro [67]

Differences in diet and food habits between patients with gallstones and controls

pylori infection also induces systemically inflammatory immune responses in the host (Jackson et al., 2009)

For example, activation of transient receptor potential ankyrin 1 (TRPA1) induces Ca influx, promoting calmodulin-dependent protein kinase II (CaMKII) phosphorylation, and Nrf2 nuclear translocation, which upregulates GPX4 to inhibit ferroptosis in high-glucose-exposed endothelial cells, thereby improving cell migration, proliferation, and tube formation to enhance diabetic wound healing [87]