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Accordingly, in a study of the aging human brain, Boumezbeur and co-authors employed 1 H and 13 C MRS, and identified a correlation between levels of glutamate and N -acetylaspartate (taken as marker of neuronal integrity) and the TCA cycle rate in neurons, as well as between the levels of myo -inositol (a putative glial marker, discussed in [10]) and the TCA cycle rate in glial cells [116]

We observed that the mRNA expression of Iba-1 , a panmicroglial marker, and CD68 , a marker of phagocytic microglia, was significantly increased in the hippocampus of test mice, whereas a trend toward an increase in the expression of a Gfap marker in the hippocampus was also observed notable evidence of glial cell activation

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