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Kovacic P: Role of oxidative metabolites of cocaine in toxicity and addiction: oxidative stress and electron transfer

Farnesyltransferase inhibitors reverse the proliferative phenotype in Nf1 -deficient mouse cells, and can reverse spatial learning impairments in a mouse model of NF1 , by decreasing RAS levels.6 These observations have prompted investigations into the use of farnesyltransferase inhibitors for the treatment of NF-1-related complications, such as rapidly growing plexiform neurofibromas

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[Google Scholar] Reichlin T., Hochholzer W., Bassetti S., Steuer S., Stelzig C., Hartwiger S., et al