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To elucidate the specific signaling pathways activated by cytokines, we examined several pathways commonly associated with cytokine signaling, including Janus kinase (JAK)/signal transducer and activator of transcription (STAT), nuclear factor-B (NF-B), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3kinase (PI3K)/protein kinase B (AKT)