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Notable recent developments include the first preclinical study demonstrating NNMT inhibition improves cardiac function and reduces fibrosis in a heart failure model (Li et al., 2025), a comprehensive review of NNMT as a therapeutic target for neurodegenerative disorders (Liu et al., 2025), and emerging evidence that NNMT inhibition counteracts tubular senescence and fibrosis in chronic kidney disease

If the patient is given a 1mg tablet of B12 and absorbs 1% of it then he or she will be absorbing around 10mcg of the vitamin

The limited blood supply compounds this problem by restricting the delivery of fibroblasts and growth factors needed for repair

Inhibiting NNMT increases cellular NAD+ levels, which activates sirtuin pathways and promotes fatty acid oxidation