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In the case of LC and infectious ME/CFS, adjuvants that could induce hyperactivation and depletion of the immune system by chronic exposure would be viral antigens, interacting with genetically predisposed HLA-II alleles (HLA-DRB1), similar to ASIA syndrome (61)

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Additionally, based on density functional theory, we developed a computational model to predict the K d values and the trend of reaction kinetics of Michael addition reactions 30