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In the unaffected colonic mucosa of colorectal cancer patients, although the frequencies of T cells and tissue-resident memory T cells are decreased, the B cell memory response to commensal bacteria is significantly enhanced, accompanied by an increased proportion of effector memory B cells, transitional B cells, and plasma cells in peripheral blood [49]

Thus, it is not surprising that GSH (or the [GSH]/[GSSG] ratio) plays a key role in many diseases including cancer, inflammation, Alzheimer's disease, Parkinson's disease, sickle cell anemia, liver disease, cystic fibrosis, AIDS, heart attack, stroke, and diabetes [4, 6] as well as in aging [79]

Too-high levels of oxidative stress may be a precursor to multiple diseases