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Description

Khodam Hazrati M, Vcha R

The reduced BODIPY appeared red and the oxidized BODIPY was green

Therefore, targeting GLS to block GLN degradation is a promising therapeutic strategy

This review integrates mechanistic insights with translational advances, outlining how dysregulation of chaperones, autophagy-mitophagy, the ubiquitinproteasome system, and ER stress pathways drive human diseases, while highlighting emerging therapeutic platforms, from pharmacological chaperones and autophagy modulators to targeted protein degradation technologies, CRISPR screens, spatial biology, and AI-guided drug discovery