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The actual mechanism is likely to occur via two sequential steps with semiquinone (SQ . ) and superoxide (O2 . ) intermediates

After that period, the doses should be reduced to one or two injections per month or as prescribed by the doctor

Statins, besides lowering lipids, can inhibit RANKL expression and inhibit osteoclast precursor differentiation, suggesting potential value for bone protection in RA (185)