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4E, bottom panel) revealed strong enrichment of glycine and serine metabolism, arginine and proline metabolism, the urea cycle, the Warburg effect, alanine metabolism, aspartate metabolism, glutamate metabolism, and methionine metabolism, with additional overrepresentation in pathways linked to nucleotide metabolism, gluconeogenesis, the pentose phosphate pathway, and pyruvate metabolism

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It's produced by the liver and is involved in many body processes, including tissue building and repair, immune system function, and making chemicals and proteins

(3) Oxidative stress reinforced the nuclear p53progerin interaction to accelerate hepatocyte premature senescence