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223,224 The most widespread modification methods include backbone, ribose, and nucleobase modifications

Joyal et al

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However, the GSH consumed for the initial reactions that are catalyzed by formaldehyde dehydrogenase and glyoxalase 1 will not cause a loss in GSH content as the GSH used as substrate for the initial reactions is regenerated (Figure 2) during the further reactions (Allaman et al